首页> 外文期刊>Journal of the European Academy of Dermatology and Venereology: JEADV >Cutaneous hyperpigmentation induced by omeprazole mimicking ashy dermatosis.
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Cutaneous hyperpigmentation induced by omeprazole mimicking ashy dermatosis.

机译:由奥美拉唑模拟的无性皮肤病引起的皮肤色素沉着过度。

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摘要

BACKGROUND: Omeprazole has been associated with multiple adverse effects including skin reactions but, to date, cutaneous hyperpigmentation has not been described as an adverse effect of this drug. OBSERVATIONS: We describe a case of a 52-year-old Caucasian woman who developed skin hyperpigmentation in the upper trunk, mimicking ashy dermatosis, 2 months after initiating omeprazole treatment. Histopathologic examination of a skin biopsy taken from a pigmented macule showed dermal macrophages containing golden-brown granules, which also displayed a sulphur peak on energy-dispersive X-ray microanalysis. High-performance liquid chromatography (HPLC) and mass spectrometry were also performed on the drug and on a biopsy specimen revealing the same chromatograms as well as the same mass spectra. CONCLUSIONS: According to our results, omeprazole itself may induce cutaneous pigmentation and, to our knowledge, this is the first report of this finding.
机译:背景:奥美拉唑与多种不良反应相关,包括皮肤反应,但迄今为止,皮肤色素沉着尚未被描述为该药物的不良反应。观察:我们描述了一个52岁的白人妇女,该妇女在开始奥美拉唑治疗后2个月,在上躯干出现了色素沉着过度,模仿了灰hy的皮肤病。从有色素的黄斑进行的皮肤活检的组织病理学检查显示,皮肤巨噬细胞含有金棕色颗粒,在能量分散型X射线显微分析中也显示出硫峰。还对该药物和活检标本进行了高效液相色谱(HPLC)和质谱分析,结果显示相同的色谱图和相同的质谱图。结论:根据我们的研究结果,奥美拉唑本身可能诱导皮肤色素沉着,据我们所知,这是该发现的首次报道。

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