Dependence of lonization Constants of Ephedrine in Aqueous and Non-aqueous Media

摘要

lonization constants of ephedrine are measured at different temperatures(25,30,35,40,45 & 50deg C)and in mixed organic-water solvent mixtures(dioxane-water,acetic acid-water,ethanol-water,methanol-water,acetonitrile-water and propylene carbonate-water)at 25deg C.Data were obtained for the dissociation of ephedrine with particular emphasis on the effect of temperature and nature of solvent on pkt values.Potentiometric data obtained were analysed by computer program.Results shows that as temperature increases,pk_b values decreases.Also pkb values are higher in mixed solvent systems than in aqueous media.