Chemical constituents of the japanese liverworts Odontoschisma denudatum, Porella japonica, P. acutifolia subsp. tosana and Frullania hamatiloba

摘要

From the ether extracts of Japanese liverworts, Odontoschisma denudatum, Porella japonica, Porella acutifolia subsp. tosana and Frullania hamatiloba, various new terpenoids were isolated. They contain dolabellane-, labdane-, fusicoccane-, ent-vibsane-and denudatane-type diter-penoids, guaiane- and pinguisane-type sesquiterpenoids, Diels-Alder reaction-type pinguisane dimers, flavone and flavanone. The crude extract of Porella japonica showed the strong cathepsin B and L inhibitory activities.