Potential correlation of intrathecal baclofen concentration and clinical improvement after high dose intrathecal intoxication: a case report.

摘要

Baclofen, a derivate of Gamma-amino butyric acid (GABA), is a muscle relaxant used for treatment of the spasticity in different neuromuscular disorders like multiple sclerosis, cerebral palsy and spinal cord injuries. This GABA agonist elicits amelioration of motor movement and thereby improves spastic symptoms. Intrathecal baclofen administration is an alternative to oral therapy, which is limited by relative higher side effects and less bioavail-ability as intrathecal therapy [1,2]. In addition, the intrathecal therapy is more effective due to direct application of baclofen into the cerebrospinal fluid. Baclofen pump implantation for continuous intrathecal application is a well known treatment option.