Cetyltrimethylammonium bromide-surfactant aqueous micelles as a green and ultra-rapid reactor for synthesis of 5-oxo-2-thioxo-2,5-dihydro-3-thiophenecarboxylate derivatives

摘要

Aqueous cetyltrimethylammonium bromide-surfactant micelles were found to be an efficient and rapid reactor system for the synthesis of rhodanine by a three-component reaction of amine, carbon disulfide, and activated acetylene. The advantages of this method are the use of a water medium and a simple and easy workup resulting in a green and direct synthetic method to give excellent yields of rhodanine derivatives.