Estimation of sulfur by gas-phase molecular absorption spectroscopy (GPMAS) and use in pharmaceutical analysis

摘要

In the present study, gas-phase molecular absorption spectroscopy (GPMAS) is used to estimate sulfur in organic compounds and drugs. Organosulfur compounds or drugs were fused with sodium (metal) to convert available sulfur to sodium sulfide, followed by dissolution in water. Afterwards, the filtered solution was treated with sulfuric acid (concentrated) to release H2S. Hydrogen sulfide swept with nitrogen into a long absorption cell through which light of wavelength 198 nm produced by suitable lamp passed to record absorbance. The proposed method was also used to find out the effect of concentration and time on the stability of sulfide solutions. The method has low standard deviation and can produce accurate results down to 2 μg/mL~(-1) sulfide concentration.