Correlating liposomal adjuvant characteristics to in- vivo cell-mediated immunity using a novel Mycobacterium tuberculosis fusion protein: a multivariate analysis study

Kastner Elisabeth; Hussain M. Jubair; Bramwell Vincent W.; Christensen Dennis; Perrie Yvonne

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Correlating liposomal adjuvant characteristics to in- vivo cell-mediated immunity using a novel Mycobacterium tuberculosis fusion protein: a multivariate analysis study

机译：使用新型结核分枝杆菌融合蛋白将脂质体佐剂特性与体内细胞介导的免疫相关性：多变量分析研究

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ObjectiveIn this study, we have used a chemometrics-based method to correlate key liposomal adjuvant attributes with in-vivo immune responses based on multivariate analysis.

机译：目的在这项研究中，我们基于多变量分析，使用了基于化学计量学的方法将关键的脂质体佐剂属性与体内免疫应答相关联。

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来源
《Journal of Pharmacy and Pharmacology》 |2015年第3期|共14页
作者
Kastner Elisabeth; Hussain M. Jubair; Bramwell Vincent W.; Christensen Dennis; Perrie Yvonne;
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正文语种 eng
中图分类药理学;
关键词
in-vivo correlation; liposome; multivariate analysis; subunit vaccine;

机译：体内相关;脂质体;多变量分析;亚单位疫苗;

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专利

1. Correlating liposomal adjuvant characteristics to in- vivo cell-mediated immunity using a novel Mycobacterium tuberculosis fusion protein: a multivariate analysis study [J] . Kastner Elisabeth, Hussain M. Jubair, Bramwell Vincent W., Journal of Pharmacy and Pharmacology . 2015,第3期

机译：使用新型结核分枝杆菌融合蛋白将脂质体佐剂特性与体内细胞介导的免疫相关性：多变量分析研究
2. Cell-mediated immune responses and protective efficacy against infection with Mycobacterium tuberculosis induced by Hsp65 and hIL-2 fusion protein in mice. [J] . Shi C, Yuan S, Zhang H, Scandinavian journal of immunology. . 2009,第2期

机译：Hsp65和hIL-2融合蛋白在小鼠中诱导的细胞介导的免疫反应和针对结核分枝杆菌感染的保护作用。
3. Immunization with extracellular proteins of Mycobacterium tuberculosis induces cell-mediated immune responses and substantial protective immunity in a guinea pig model of pulmonary tuberculosis. [J] . P G Pal, M A Horwitz Infection and immunity . 1992,第11期

机译：在肺结核的豚鼠模型中，结核分枝杆菌的细胞外蛋白免疫诱导细胞介导的免疫反应和实质性保护性免疫。
4. Pulmonary delivery of microencapsulated ESAT-6 from Mycobacterium Tuberculosis is superior toparenteral delivery methods for inducing specific cell-mediated immune responses [C] . Z. K. Carpenter, J. E. Eyles, E. D. Williamson Controlled Release Society annual meeting . 2004

机译：结核分枝杆菌的微囊化ESAT-6的肺部递送优于胃肠外递送方法，可诱导特定的细胞介导的免疫反应
5. In vivo characterization of the adjuvant effect of Mycobacterium tuberculosis hsp70. [D] . Harmala, Lisa Ann Engen. 2004

机译：结核分枝杆菌hsp70佐剂作用的体内表征。
6. Immunization with extracellular proteins of Mycobacterium tuberculosis induces cell-mediated immune responses and substantial protective immunity in a guinea pig model of pulmonary tuberculosis. [O] . P G Pal, M A Horwitz 1992

机译：在肺结核的豚鼠模型中结核分枝杆菌的细胞外蛋白免疫诱导细胞介导的免疫反应和实质性保护性免疫。
7. Correlating liposomal adjuvant characteristics to in-vivo cell-mediated immunity using a novel Mycobacterium tuberculosis fusion protein : a multivariate analysis study [O] . Kastner Elisabeth, Hussain M. Jubair, Bramwell Vincent W., 2015

机译：使用新型结核分枝杆菌融合蛋白将脂质体佐剂特性与体内细胞介导的免疫相关性：多变量分析研究

Correlating liposomal adjuvant characteristics to in- vivo cell-mediated immunity using a novel Mycobacterium tuberculosis fusion protein: a multivariate analysis study

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