A gastro-resistant ovalbumin bi-layered mini-tablet-in-tablet system for the delivery of Lactobacillus acidophilus probiotic to simulated human intestinal and colon conditions

Govender Mershen; Choonara Yahya Essop; van Vuuren Sandy; Kumar Pradeep; du Toit Lisa Claire; Pillay Viness

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A gastro-resistant ovalbumin bi-layered mini-tablet-in-tablet system for the delivery of Lactobacillus acidophilus probiotic to simulated human intestinal and colon conditions

机译：一种胃耐性卵清蛋白双层微型片对片系统，用于将嗜酸乳杆菌益生菌递送至模拟的人类肠道和结肠疾病

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ObjectivesThe viability of probiotic bacteria during formulation processes and delivery is vital to ensure health benefits. This study focuses on the use of gastro-resistant denatured ovalbumin for the targeted delivery of probiotic Lactobacillus acidophilus to simulated human intestinal and colon conditions through a bi-layered mini-tablet-in-tablet system (BMTTS).

机译：目的益生菌在配制过程和输送过程中的生存能力对确保健康有益至关重要。这项研究的重点是通过双层微型平板电脑对平板电脑系统（BMTTS）将胃抗性变性卵清蛋白用于将益生菌嗜酸乳杆菌靶向递送到模拟的人的肠道和结肠疾病。

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《Journal of Pharmacy and Pharmacology》 |2015年第7期|共12页
作者
Govender Mershen; Choonara Yahya Essop; van Vuuren Sandy; Kumar Pradeep; du Toit Lisa Claire; Pillay Viness;
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正文语种 eng
中图分类药理学;
关键词
bi-layered mini-tablet-in-tablet; gastro-resistant; intestinal and colon targeting; Lactobacillus acidophilus; ovalbumin;

机译：双层微型片剂;耐胃液;肠和结肠靶向;嗜酸乳杆菌;卵清蛋白;

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1. A gastro-resistant ovalbumin bi-layered mini-tablet-in-tablet system for the delivery of Lactobacillus acidophilus probiotic to simulated human intestinal and colon conditions [J] . Govender Mershen, Choonara Yahya Essop, van Vuuren Sandy, Journal of Pharmacy and Pharmacology . 2015,第7期

机译：一种胃耐性卵清蛋白双层微型片对片系统，用于将嗜酸乳杆菌益生菌递送至模拟的人类肠道和结肠疾病
2. Oral inoculation of probiotics Lactobacillus acidophilus NCFM suppresses tumour growth both in segmental orthotopic colon cancer and extra-intestinal tissue. [J] . Chien-Chang Chen Wei-Chuan Lin Man-Shan Kong Hai Ning Shi Walker H. A, Chun-Yen Lin Ching-Tai Huang Yung-Chang Lin Shih-Ming Jung Tzou-Yien Lin The British Journal of Nutrition . 2012,第11期

机译：口服益生菌嗜酸乳杆菌 NCFM可以抑制节段性原位结肠癌和肠外组织中的肿瘤生长。
3. Oral inoculation of probiotics Lactobacillus acidophilus NCFM suppresses tumour growth both in segmental orthotopic colon cancer and extra-intestinal tissue [J] . Chien-Chang Chen, Ching-Tai Huang, Chun-Yen Lin, The British Journal of Nutrition . 2011,第11期

机译：益生菌嗜酸乳杆菌NCFM的口服接种可抑制节段性原位结肠癌和肠外组织中的肿瘤生长
4. A NEW COLON SPECIFIC DRUG DELIVERY SYSTEM: FORMULATION AND GAMMASCINTIGRAPHIC EVALUATION IN HEALTHY HUMAN VOLUNTEERS [C] . F. J. Ahmad, R. K. Khar International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：一种新型的结肠特定药物输送系统：人体健康志愿者的配方和γ谱评估
5. Effects of Prebiotic fibre Diets on Rat Mucosal Intestinal and Systemic Immunity and in Vitro Mechanistic Analysis of Anti-Inflammatory Effects of Lactobacillus Strains on Rat and Human Intestinal Epithelial Cells. [D] . McCarville, Justin. 2012

机译：益生元纤维饮食对大鼠粘膜肠和全身免疫的影响以及乳酸菌对大鼠和人肠上皮细胞抗炎作用的体外机理分析。
6. Eruca sativa Might Influence the Growth, Survival under Simulated Gastrointestinal Conditions and Some Biological Features of Lactobacillus acidophilus, Lactobacillus plantarum and Lactobacillus rhamnosus Strains [O] . Florinda Fratianni, Selenia Pepe, Federica Cardinale, 1997

机译：紫草可能在模拟胃肠道条件下影响生长，存活以及嗜酸乳杆菌，植物乳杆菌和鼠李糖乳杆菌菌株的某些生物学特性。
7. Effects of added Lactobacillus acidophilus and Bifidobacterium lactis probiotics on the quality characteristics of goat ricotta and their survival under simulated gastrointestinal conditions [O] . Meira Quênia Gramile Silva, Magnani Marciane, de Medeiros Júnior Francisco Cesino, 2015

机译：添加嗜酸乳杆菌和乳酸双歧杆菌益生菌对山羊乳清干酪品质特性及其在模拟胃肠道条件下存活的影响
8. Persistence of Lactobacillus Reuteri DSM17938 in the Human Intestinal Tract: Response to Consecutive and Alternate-Day Consumption with Varying Storage Conditions [R] . Smith, T. J., Anderson, D., Margolis, L. M., 2011

机译：罗伊氏乳杆菌Dsm17938在人类肠道中的持久性：对不同储存条件下的连续和替代日消耗的反应

A gastro-resistant ovalbumin bi-layered mini-tablet-in-tablet system for the delivery of Lactobacillus acidophilus probiotic to simulated human intestinal and colon conditions

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