Dexamethasone eluting electrodes for cochlear implantation: Effect on residual hearing

摘要

Objective: The aim of this study was to compare a cochlear implant electrode array loaded with dexamethasone (DXM) with a conventional passive electrode array for the preservation of residual hearing in gerbils. Methods: Thirty Mongolian gerbils (Meriones unguiculatus) were implanted with an eluting electrode loaded with DXM (1 and 10%) on one side and a conventional passive electrode on the other side. Hearing thresholds were determined by tone bursts auditory brainstem responses at 4–6 weeks post-implantation and 1-year post-implantation for older gerbils. Results: After 4–6 weeks post-implantation, residual hearing was statistically more preserved with electrode arrays loaded with DXM, regardless of concentration, for the frequencies 16 000 Hz (P = 0.0008), 4000 Hz (P = 0.0038), 1000 Hz (P = 0.0349), and 500 Hz (P = 0.0030). After 1 year, the difference in favor of the DXM+ electrode array was found statistically significant only for the frequency 16 000 Hz (P = 0.0103) but against it for the frequencies 1000 Hz (P = 0.0368) and 500 Hz (P = 0.0010). Conclusion: Electrode array with prolonged release of DXM improved short-term preservation of residual hearing after implantation for the frequencies 500, 1000, 4000, and 16 000 Hz in gerbils. The long-term results at 1 year confirmed these data for higher frequencies, but must be verified for the lower frequencies of 500 and 1000 Hz.