Sinusoidal obstruction syndrome is a major feature of hepatic lesions associated with oxaliplatin neoadjuvant chemotherapy for liver colorectal metastases.

摘要

We read with great interest the article by Fernandez and colleagues published in the June 2005 issue, entided "Effect of steatohepatitis associated with irinotecan or oxaliplatin pretreatment on resectability of hepatic colorectal metastases." In their series of 37 hepatic resections for colorectal metastasis, the authors demonstrated an increase in histologic liver injury among the 14 patients treated with oxaliplatin and irinotecan compared with the 23 patients treated by surgery alone or by 5-FU and surgery. The authors concluded that new chemotherapeutic agents may lead to liver injury. Their results confirm our series on 157 hepatic resections for colorectal metastasis in which hepatic lesions developed in more than 80% of oxaliplatin-treated patients.