The individual components of the metabolic syndrome: is there a raison d'etre?

摘要

This article summarizes the evidence indicating that the abnormalities that comprise all versions of the metabolic syndrome (MetS) do not 'cluster' together by accident, and that a defect in insulin action, and its consequences, plays a fundamental role in the development of the cardiovascular disease risk factors that comprise all versions of the MetS. Insulin resistance/hyperinsulinaemia and the components of the Mets, such as obesity, glucose intolerance, dyslipidaemia and blood pressure are discussed..