Carotid ultrasound, coronary calcium, and dyslipidemia patterns in the MESA (Multi-Ethnic Study of Atherosclerosis) cohort.

摘要

In this issue of the Journal, Paramsothy et al. (1) relate coronary artery calcium (CAC) scores and intima-media thickness (IMT) measurements to patterns of dyslipidemia. Because much of current practice is dictated by such patterns, the authors did not attempt to take into account family history, physical findings, apolipoproteins, and other tests to determine specific diagnoses such as heterozygous familial hypercholesterolemia or familial combined hyper-lipidemia. Instead, the paper used operational definitions based on the dominant lipid abnormality (in order of severity: a combination of high triglycerides [TG] and high low-density lipoprotein cholesterol [LDL-C], isolated high LDL-C, increased TG with low high-density lipoprotein cholesterol [HDL-C], termed dyslipidemia of metabolic syndrome, isolated hyper-TG, and isolated low HDL).