Nonhypotensive low-dose nesiritide has differential renal effects compared with standard-dose nesiritide in patients with acute decompensated heart failure and renal dysfunction.

摘要

Further prospective randomized controlled studies are warranted to test the efficacy of non-hypotensive low-dose nesiritide such as 0.005 mug/kg/min and the current dose of 0.01 mug/kg/min without the bolus of 2 mug/kg/min in enhancing renal function in patients with acute decompensated CHF and renal dysfunction as well as defining the mechanisms of the renal-enhancing actions of such a strategy.