Comparative evaluation of different cultivars of Flos Chrysanthemi by an anti-inflammatory-based NF-kappa B reporter gene assay coupled to UPLC-Q/TOF MS with PCA and ANN

摘要

Ethnopharmacological relevance: Flos Cluysanthemi (FC), a commonly used traditional Chinese medicine, has five major cultivars ("Boju", "Chuju", "Gongju", "Hangbaiju" and "Huaiju") from different sources. However, the active constituents of these cultivars have not been studied or characterized with respect to their bioactivity, which is a serious problem when considering quality and safety.