Synthesis of Bioactive and Porous Organic-Inorganic Hybrids for Biomedical Applications

摘要

Bioactivity has been exhibited by a limited range of ceramics since the invention of Bioglass.Recently,some bioactive polymeric organic-inorganic hybrids were introduced,including not only organically modified silicates (Ormosils) synthesized from polydimethylsiloxane (PDMS) and tetraethoxysilane but also those with gelatin and 3-glycidoxypropyl-tremethoxysilane.Preparation of the bulk and porous hybrids and their polymeric structures analyzed by Si NMR spectroscopy were presented.In vitro bioactivity or apatite deposition in a simulated body fluid of the Kokubo recipe were also described for those hybrids.Freeze-drying techniques introduced porosity (up to 90%) and pores extending in a preferred direction.