Colorectal cancer (CRC) is the second most common cause of cancer deaths in developed countries, with 35,000 new cases and 16,000 deaths in the UK in 2004 (Fig I). There have been significant improvements in CRC survival over the last decade (5-year survival is now about 50%) but the UK still lags behind the USA and most of Western Europe. One of the main reasons is late presentation; early-stage tumours (TNM stage I/II) have a good to excellent five-year survival (65-95%) with surgery alone, but in the UK only about 40% of colorectal cancers are diagnosed at early stages.
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机译：在发达国家，大肠癌（CRC）是第二大最常见的癌症死亡原因，2004年英国有35,000例新病例，而16,000例死亡（图I）。在过去十年中，CRC生存率有了显着提高（5年生存率现在约为50％），但英国仍落后于美国和西欧大部分地区。主要原因之一是迟到。早期肿瘤（TNM I / II期）仅通过手术即可达到良好的五年生存期（65-95％），但在英国，只有约40％的大肠癌在早期被诊断出来。
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