Cardiovascular risk and inflammatory rheumatic diseases

摘要

Patients with chronic inflammatory rheumatic conditions such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), spondyloarthritis (psoriatic arthritis and ankylosing spondylitis) and juvenile idiopathic arthritis (JIA) are at increased risk of developing premature cardiovascular disease (CVD). The pathogenesis of CVD in these conditions is multi-factorial and is thought to result from an interaction of inflammation, metabolic factors, therapy and disease-related factors. This review provides an overview of the current understanding of CVD risk factors in patients with inflammatory rheumatic diseases. Better understanding of the association between these conditions and cardiovascular morbidities can help in early assessment and management of risk factors; in turn, this may help to improve long-term outcomes in patients with inflammatory rheumatic disease.