Tc-99m-3P-RGD2 molecular imaging targeting integrin alpha (v) beta (3) in head and neck squamous cancer xenograft

摘要

Tc-99m-3P-RGD2 and SPECT/CT were valuable tools for selecting patient likely benefit from integrin alpha (v) beta (3) blocking therapy. To evaluate the feasibility of Tc-99m-3P-RGD2 imaging to detect head and neck squamous cell carcinoma, Tc-99m-3P-RGD2 was prepared and the relationship between its accumulation and integrin alpha (v) beta (3) expression in nude mice bearing HEP-2 or CNE-1 carcinoma xenograft were analyzed. This study demonstrated that Tc-99m-3P-RGD2, with high affinity to integrin alpha (v) beta (3), will provide basis for alpha (v) beta (3) involved individual therapy.