Preparation of ~(99)Mo/~(99m)Tc generator based on alumina ~(99)Mo-molybdate (VI) gel

摘要

In this work alumina ~(99)Mo-molybdate (VI) gel is evaluated as a column matrix for use in the preparation of small chromatographic column type ~(99m)Tc generator. Alumina molybdate (VI) gel is prepared by dissolving inactive MoO3 with aluminum foil in 5 M NaOH solution containing ~(99)Mo radiotracer. After complete dissolution, 0.5 H_2O_2 was added to the reaction mixture solution and acidified to pH 5.5 with concentrated HNO_3. The formed AlMo precipitate was washed with NaNO_3 solution, dried at 50 ℃ for 24 h and then packed in the form of a chromatographic column for elution of the generated ~(99m)Tc radionuclide with physiological saline solution (0.9 % NaCl). Greater than 86 % of the generated ~(99m)Tc activity is immediately and reproducibly eluted with passing 10 mL of the saline solution through 2.0 g of alumina ~(99)Momolybdate column bed at a flow rate of about 1.0 mL/min. The high radiochemical ≥98.6 % TcO_4~-, radionuclidic ≥99.90 % ~(99m)Tc and chemical purities of the eluates satisfy the specifications for use in nuclear medicine.