Preparation and the biodistribution study of [~(131)I]-5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin and 5-(4-aminophenyl)-10,15,20-triphenylporphyrin

摘要

[~(131)I]-5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin and [~(131)I]-5-(4-aminophenyl)-10,15,20-triphenylporphyrin (~(131)I-TPPOH and ~(131)I-TPPNH_2) were prepared and their biodistribution properties were evaluated in normal Kunming (KM) mice and SMMC-7721 tumor-bearing BALB/c mice. The optimized labeling yields were 98 and 96 % for ~(131)I-TPPOH and ~(131)I-TPPNH_2, respectively. They were stable in vitro saline and in vivo. Both compounds had a specific affinity to liver and lung, and mainly metabolized through liver. They showed a time-dependent accumulation and retainable characteristics in SMMC-7721 tumor. These results supported their potential value for targeted tumor therapy agents.