Production, nano-purification, radiolabeling and biodistribution study of [~(140)Nd] 5,10,15,20-tetraphenylporphyrin complex as a possible imaging agent

摘要

[~(140)Nd] labeled 5,10,15,20-tetraphenylporphyrin ([~(140)Nd]-TPP) as a tumor-avid complex with a β-emitting radionuclide for evaluating its potential for target tumor therapy is reported. This complex was prepared using freshly prepared [~(140)Nd] NdCl _3 (purified by amino functionalized MCM-41 nano resin and commercial cation exchanger resins) and 5,10,15,20-tetraphenylporphyrin (H _2TPP).Stability of the complex was investigated in final formulation and human serum for 24 h and the partition coefficient was calculated. The biodistribution of the labeled compound in vital organs of Swiss mice bearing fibro sarcoma tumor was studied using scarification studies and positron emission tomography imaging up to 4 h.