Radio synthesis and in vivo evaluation of two alpha 7 nAChRs radioligands: [I-125]CAIPE and [I-125]IPPU

摘要

The radio synthesis and in vivo evaluation of two alpha 7 nAChRs radioligands [I-125]CAIPE and [I-125]IPPU were reported. They were obtained from their tributyltin precursors with high radio chemical yields (>90 %) and good radio chemical purities (>95 %). Biodistribution and blockade studies of [I-125] CAIPE showed that the accumulation of radioactivity in the mouse brain was specific and selective.