Comparative biological parameters for the evaluation of common renal pharmaceutical preparations: Tc-99m-DTPA, Tc-99m-GH, and Tc-99m-DMSA

摘要

This work is concerned on establishing the necessary comparative quality control biological parameters for the evaluation of locally produced renal pharmaceutical preparations viz. tin complexes of Tc-99m-DTPA, Tc-99m-GH, and Tc-99m-DMSA using gel chromatography column scanning techniques. Radiochemical purity, labeling yields, organ distribution, blood clearance and plasma protein binding were used as a selected indicator for quality control. The higher renal accumulation and tissue distribution were apparent with Tc-99m-DTPA in mice, while blood retention was considerably low. The blood clearance of Tc-99m-DMSA was relatively slow, while that of Tc-99m-GH was rapid. The binding of Tc-99m-DTPA, Tc-99m-GH and Tc-99m-DMSA with plasma protein were found to be 5, 65, and 95 % at 1.0 h, respectively. The stability of these cold kits was not affected on storing at 37 degrees C for 30 days.