Development and validation of a robust analytical method for the determination of Cr-51 in blood samples by liquid scintillation counting (LSC)

摘要

A robust analytical method for the measurement of Cr-51 in blood samples in routine mode by means of liquid scintillation count was developed and validated with spiked blood samples from different subjects. Prior to the measurements, the samples were microwave digested in order to eliminate the matrix influence. Figures of merits, such as sensitivity, limits of detection, precision and accuracy were studied and confirmed the capability of the method to determine Cr-51 in blood samples as low as 0.5 Bq g(-1) of sample.