Nipple-sparing mastectomy: What is the frontier between oncologic safety and cosmetic outcome?

摘要

There is growing interest in nipple-sparing mastectomy (NSM) among patients and breast surgeons. However, some points still have not been clarified. A recent study investigated risk factors for recurrence in 934 NSM patients.1 In patients with invasive carcinoma (n = 772), the local recurrence (LR) rate in the breast and nipple-areola complex (NAC) was 3.6% and 0.8%, respectively. In the intra-epithelial neoplasia group (n = 162), LR-rate was 4.9% in the breast and 2.9% in the NAC. The authors observed that age (<45 years) was a risk factor for LR in the breast and NAC after intraepithelial carcinoma and tumor size, receptor status, HER-2eu, grade and Ki-67 were associated with risk of NAC recurrence after invasive carcinoma.1