Elderly subjects do not show impaired pneumococcal capsular polysaccharide serotype-specific antibody responses as assessed by a multiplexed bead assay.

摘要

In a recent manuscript, we evaluated a multiplexed bead-based assay (xMAP~R Pneumococcal Immunity assay from Luminex~R) for the simultaneous determination of antibodies against 14 pneumococcal capsular polysaccharides [1]. Post-vaccination (Pneumo23~R) antibody concentrations were measured in 75 healthy young subjects and in 123 patients with increased susceptibility to respiratory infection.In this letter, we report on serotype-specific antibody response to pneumococcal capsular polysaccharides in elderly by multiplexed bead assay. Fifty-eight healthy elderly [age range 58-92 years (mean 76 years)] were vaccinated with Pneumo23® and the pre- and post-vaccination antibody concentrations to 14 serotypes (PS1, PS3, PS4, PS6B, PS7F, PS8, PS9N, PS9V, PS12F, PS14, PS18C, PS19A, PS19F, PS23F) were compared with pre- and post-vaccination antibody concentrations in 74 healthy young subjects (age range 5-30 years (mean 15 years)]. The results are shown in Table 1. The Danish nomenclature is used for description of serotvpes.