Effects of topical mitomycin C on the ciliary body and intraocular pressure after PRK: an experimental study.

摘要

PURPOSE: To investigate the effects of the application of mitomycin C (MMC) after photorefractive keratectomy (PRK) on the ciliary body and intraocular pressure (IOP) in an experimental model. METHODS: Forty eyes of 20 rabbits underwent PRK to correct -8.00 diopters (D) in a 5-mm optical zone. Sterile surgical sponges (5 mm) soaked with 0.02% MMC were applied to corneas with the epithelium removed. Eyes were randomly chosen to receive MMC for 2 minutes (study group), and sponges soaked with balanced salt solution were applied on the contralateral eye (control group) for 2 minutes. Histological evaluation of the ciliary body was performed in a masked fashion by light and transmission electron microscopy. RESULTS: Histological examination of the morphology of the ciliary body structures revealed no differences between the two groups. Tonometric measurements of the IOP remained stable during the follow-up period with no significant changes (P=.75). CONCLUSIONS: Adjuvant application of MMC after PRK does not appear to induce alterations on the ciliary body or changes in IOP measurements.