Circular dichroism spectroscopy and other methods are used to show that the addition of dimethylsulfoxide causes reversible folding of the (GA)(10) strand of DNA into an ordered single-stranded conformer. The ordered conformer melts in a cooperative way and it does not contain protonated adenine. The (TA)(10), (A)(20), and (G)(20) are all unstable in this conformer. To the best of our knowledge, this is the first known ordered conformer of DNA that is stabilized by dimethylsulfoxide. This conformer might be a DNA analog of the protein alpha helix, which is an interesting idea for thinking about the evolution of DNA. (C) 2001 John Wiley & Sons, Inc. [References: 23]
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机译：圆二色光谱和其他方法用来表明添加二甲基亚砜会导致DNA的（GA）（10）链可逆地折叠成有序的单链构象体。有序的构象异构体以协同方式熔化，并且不包含质子化的腺嘌呤。 （TA）（10），（A）（20）和（G）（20）在该构象异构体中都不稳定。据我们所知，这是被二甲基亚砜稳定的第一个已知的有序DNA构象体。该构象体可能是蛋白质α螺旋的DNA类似物，这对于思考DNA的进化是一个有趣的想法。 （C）2001 John Wiley＆Sons，Inc. [参考：23]
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