Online UPLC Applications for Biotherapeutic Development(PPT)

摘要

1. Process Analytical Technologies (PAT) at Merck 1.1 Continuous Processing and Facility of the Future 1.2 Real Time Release Testing 2. BioProcess Case Studies w/ Online UPLC 2.1 RP-UPLC for Titer 2.2 UP-SEC 2.2.1 Multi-Attribute Method (Titer, Purity, Excipients) 2.2.2 UF/DF for High Concentration Formulation Development 2.2.3 Parallel Sampling 3. Summary and Future Work.