Synthesis of poly(ester amide)s with lateral groups from a bulk polycondensation reaction with formation of sodium chloride salts

摘要

Poly(ester amide)s with a regular sequence and derived from diamine, dicarboxylic acid, and glycolic acid units can be easily synthesized by using a thermal polycondensation method based on the formation of metal halide salts as a driving force. These new poly(ester amide)s have tuneable properties depending on the number of methylene groups and constitute a group of materials with potential interest as biodegradable materials in applications such as surgical sutures. The present work reveals that the proposed synthesis can also be applied when esters Of L-lysine are used as a diamine unit since no secondary reactions such as transesterification occur under the required polymerization conditions. The possibility of linking compounds with pharmacological activity to the carboxylic acid groups of lysine extends the interest of the referred materials, for example, as drug delivery systems. (C) 2007 Wiley Periodicals, Inc.