Chorioamnionitis in the Pathogenesis of Brain Injury in Preterm Infants

摘要

Chorioamnionitis. or placental infection, can lead to a fetal inflammatory response syndrome (FIRS) and the release of proinflammatory cytokines.FIRS is believed to contribute to brain injuries such as cystic periventricular leukomalacia (PVL) in the premature newborn.Three meta-analyses have linked chorioamnionitis to cystic PVL and cerebral palsy. Yet, the relationship between chorioamnionitis and brain injury was attenuated in newer studies. This difference may have resulted from heterogeneity of the studies (different methodologies) reviewed, or possibly as a result of improved neonatal intensive care. Large multicenter studies using rigorous definitions of chorioamnionitis on placental pathologies, quantitative magnetic resonance techniques, and standardized follow-up assessments would help clarify the impact of chorioamnionitis on brain health and outcomes.