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Synthesis, Characterization and Antimicrobial Attributes of Gold Nanoparticles Mediated by NADH-Dependent Reductase of Streptomyces sp. DBZ-39AU Mazhari, Bi Bi Zainab (mbzainab@gmail.com) Agsar, Dayanand (dayanandagsar@gmil.com)

机译:NADH依赖的链霉菌还原酶介导的金纳米粒子的合成,表征和抗菌属性。 DBZ-39AU Mazhari,Bi Bi Zainab(mbzainab@gmail.com)阿格萨尔,达亚南德(dayanandagsar@gmil.com)

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Production of NADH-dependent nitrate reductase mediated extracellular gold nanoparticles from Streptomyces sp. DBZ-39, for their distinct characteristic properties and antimicrobial activities was the major objective of the present investigation. Defined size and distinct gold nanoparticles, obtained from biological sources in general and microbial sources in particular reveal spectacular biomedical applications. Streptomyces sp. DBZ-39 was employed as an efficient isolate for the synthesis of extracellular gold nanoparticles. The detection of amino acid residues, namely tyrosine and tryptophan in the culture broth of Streptomyces sp. DBZ-39 by UV-visible spectroscopy, confirms the role of NADH-dependent reductase in the synthesis of extracellular gold nanoparticles. Scanning and Transmission Electron Micrographs revealed the characteristic properties of extracellular gold nanoparticles in a controlled size of 24nm. X-ray diffraction analysis exhibits crystal phases of gold nanoparticles. An antiviral property of gold nanoparticles employing bacteriophages is a significant attribute and reported for the first time. The antibacterial activity of gold nanoparticles was encouraging against gram negative bacterial pathogens E. coil and Pseudomonas aeruginosa, which can be explored further for their efficacy.C1 Agsar, Dayanand; Gulbarga Univ, Dept Microbiol, A DBT Res Lab, Gulbarga 585106, Karnataka, IndiaSC Pharmacology & Pharmacy; Biochemistry & Molecular Biology; Infectious Diseases
机译:从链霉菌属物种生产NADH依赖硝酸盐还原酶介导的细胞外金纳米粒子。 DBZ-39由于其独特的特性和抗菌活性是本研究的主要目标。从普通生物资源尤其是微生物资源中获得的确定大小和独特的金纳米粒子显示出惊人的生物医学应用。链霉菌DBZ-39被用作合成细胞外金纳米颗粒的有效分离物。链霉菌属菌种培养液中氨基酸残基的检测,即酪氨酸和色氨酸。通过紫外线-可见光谱的DBZ-39证实了NADH依赖的还原酶在细胞外金纳米颗粒合成中的作用。扫描和透射电子显微照片揭示了细胞外金纳米颗粒在24nm控制尺寸下的特征。 X射线衍射分析显示金纳米颗粒的晶相。利用噬菌体的金纳米颗粒的抗病毒性质是重要的属性,并且是首次报道。金纳米颗粒对革兰氏阴性细菌病原体大肠杆菌和铜绿假单胞菌的抗菌活性令人鼓舞,可以进一步探讨其功效。 Gulbarga大学,DDB微生物部,DBT Res实验室,Gulbarga 585106,印度卡纳塔克邦,SC药理与药学;生物化学与分子生物学;传染性疾病

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