Preparation of an Allylamine Hydrochloride-Based Hydrogel: a Nonabsorbed Calcium-and Aluminum-Free Phosphate Binder

摘要

In this study, a cross-linked allylamine hydrochloride (ALH)-based hydrogel was synthesized as a potential non-absorbed chelator for phosphorus ions. The hydrogel was well-characterized by infrared spectroscopy, powder X-Ray diffraction and Scanning Electron Microscope. The binding capacities of ALH-based hydrogel were compared to commercial available preparations. The results demonstrate that ALH-based hydrogel is capable of removing phosphorus ions from dialysate effluent of which the composition is very similar to human body fluid. The ALH-based hydrogel exhibits a much better binding effect than that of medicinal charcoal tablets. The destructive tests give the result that the ALH-based hydrogel possesses a good stability in acid environment and oxidation environment, suggesting a good stability in gastrointestinal tract after oral administration. Thus, the obtained hydrogel may have potential applications in environmental management, wastewater treatment as well as treatment of hyperphosphatemia patients.