Retention Data for Some Carbonyl Derivatives of lmidazo[2,1-c][1,2,4]triazine in Reversed-Phase Systems in TLC and HPLC and their Use for Determination of Lipophilicity. Part 1. Lipophilicity of 8-Aryl-3-phenyl-6,7-dihydro-4H-imidazo[2,1 -c][1,2,4]tr

摘要

Thirteen carbonyl derivatives of imidazo [2,l-c][l,2,4]triazine have been synthesized as a new bioactive set of substances. Investigations of chromatographic retention with use of mobile phases containing different concentrations of modifier enable derivation of several characteristics indicative of lipophilicity differences among the compounds. The lipophilicity C_(MW)) of the solutes was determined by reversed-phase thin-layer chromatography (RP TLC) with aqueous mobile-phases containing organic modifiers (methanol or diox-ane) on water-wettable octadecyl silica. Reversed-phase high-performance liquid chromatography (RP HPLC) systems with aqueous mobile phases and different organic modifiers,(methanol, dioxane, acetonitrile, tetrahydrofuran) on octadecyl silica columns was also used for determination of the lipophilicity (log k_W) of the thirteen derivatives. Correlations between phi_(0_(MeOH)) values and phi_(0(modifier)) were established for all the compounds with high values of correlation coefficients (r > 0.93).