A Simple and Sensitive HPTLC Method for Simultaneous Analysis of Tolperisone Hydrochloride and Etodolac in Combined Fixed-Dose Oral Solid Formulation

摘要

Tolperisone hy drochloride (TOLP; (R,S)-2-methyl-1-(4-methylphenyl)-3piperidine-l-yl propan-1-one monohydrochloride; Figure 1) is used as a centrally acting muscle relaxant in several acute and chronic spastic conditions and arthritis [1,2]. Etodolac (ETD; (R,S)-2[1,8-diethyl-4,9-dihydro-3H-pyrano (3,4-6)indol-1-yl]acetic acid; Figure 2) is a nonsteroidal anti-inflammatory drug [3]. The combination of these drugs (150 mg TOLP and 400 mg ETD) has been recently approved for the treatment of acute inflammation condition associated with spasm. Etodolac helps to relieve the pain from inflammation during spasm, when treated by tolperisone.