Antiaflatoxigenic Activities of Some Plant Aqueous Extracts Against Aflatoxin-Bl Induced Renal and Cardiac Damage

摘要

The present investigation aims at assessing the antiaflatoxigenic effect of aqueous extracts of some traditional medicinal plants (namely, Zingiber officinale Roscoe rhizome, Cinnamomum zeylanicum bark, Trigonella foenum graecum seeds, Camellia sinensis leaves and Salvia officinalis leaves) compared to the anticancer drug, methotrexate (MTX) against aflatoxin-Bl (AFB1) induced renal and cardiac damage in rats. The results revealed that administration of AFB1 induces oxidative stress in kidneys of AFB1-treated rats through elevating the level of malondialdehyde (MDA) and depleting the levels of tissue antioxidants, glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G-6-PDH) and vitamin C. The results also showed that