Hydro-Alcoholic Media: An Emerging in vitro Tool for Predicting Dose Dumping from Controlled Release Matrices

摘要

In present study, the release profiles of hydrochlorothiazide from polyacrylic acid polymer (carbopol 71G) matrices in hydro-ethanolic media were done. Percent drug released increased with increasing levels of ethanol in the dissolution media, but there was no direct correlation with the drug's solubility in the media. Although, the result showed that an initial rapid release was observed in the media containing 30% ethanol, this could not be regarded as dose dumping of hydrochlorothiazide. Release in this medium was considered to be both erosion and diffusion-mediated, in contrast to the release in 0,10, 20, 40 and 50% ethanol media, where erosion-controlled release dominated. Image analysis of matrix swelling and swelling kinetics suggests a complex interaction between ethanol, hydrochlorothiazide and Carbopol 71 G accounting for the suppressed drug release in the ethanolic-media.