Hypoglycaemic and Antihyperglycaemic Effect of Syzygium cumini Bark in Streptozotocin-Induced Diabetic Rats

摘要

The aim of the present study was to investigate the hypoglycaemic and antihyperglycaemic effect of Syzygium cumini (S. cumini) bark in diabetic rats. Diabetes was induced in male albino Wistar rats by a single intraperitoneal injection of streptozotocin (45 mg kg"' body weight). An aqueous extract of S. cumini bark (SBEt) was administered orally (75,150 and 300 mg kg body weight) for 45 days and changes in blood glucose, urine sugar, food and fluid intakes and body weight were examined in diabetic rats. Glibenclamide was used as a standard reference drug. The levels of blood glucose and urine sugar were increased significantly in diabetic rats. Oral administration of SBEt to diabetic rats led to significantly decreased levels of blood glucose and urine sugar.