Immimotherapy of 347 Volunteer Outpatient Morphine Addicts by Human Therapeutic Morphine Vaccine in Kermanshah Province of Iran

摘要

The effective constituent of human therapeutic morphine vaccine is morphine-6-succinate-BSA which would be produced by mixed anhydride method. By injection of 3 doses of vaccine at the interval of 0-30-60 days, humoral immunity would be caused in addicts. In this study 347 morphine addicted volunteers were vaccinated with therapeutic morphine vaccine according to WHO and national vaccination protocol. The variables were doses of vaccine, concentration of anti-morphine antibody, total protein and gamaglobuline. Volunteers were bled and then injected at the interval of 0-30-60 days. All subjects were bled at day 90 and after 1 year, 10% of them were bled randomly. Total protein and gamaglobuline were determined by serum electrophoresis and anti-morphine antibody level was estimated by ELIS A.