In vitro Study on the Interaction of Caffeine with Gliclazide and Metformin in the Aqueous Media

摘要

An in vitro study of interaction of caffeine with gliclazide and metformin HC1 has been studied at room temperature and at different pH. It has been found that caffeine forms stable 1:1 molecular complexes with gliclazide and metformin HC1. The studies have been carried out by various UV spectrophotometric and conductometric methods. Observation of the UV spectra of the two molecules in presence of caffeine has indication that it reacts with the anti-diabetic agents. The