It has been an honor to serve as guest editors for this special edition of Clinics in Laboratory Medicine, entitled Prenatal Screening and Diagnosis. The last issue devoted to prenatal testing was in June 2003. Since that time, a lot of development has occurred in the arena of prenatal testing, particularly with the development of new screening paradigms for Down syndrome. This edition may seem to have more articles dedicated to aneuploidy screening compared with prior editions. The reason for this is the proliferation of new screening strategies in the past 5 years and the struggle among clinicians to adopt what is best for their population.
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