Nonequilibrium Atmospheric Plasma Jets Assisted Stabilization of Drug Delivery Carriers: Preparation and Characterization of Biodegradable Polymeric Nano-Micelles with Enhanced Stability

摘要

Polymeric micelles formed in aqueous media through self-assembly of poly(ethylene glycol)-block-poly(lactide) copolymers (PEG-b-PLA) have been extensively studied as drug delivery carriers,because PEG-b-PLA micelles possessing FDA-approved polymer components showed high biocompatibility and applicable biodegradability. Their hydrophilic PEG shells serve as a brush to avoid the protein adsorption and subsequent non-specific uptake by reticuloendothelial systems (RES) after intra-venous injection,and their hydrophobic PLA cores accommodate drugs with a high loading efficiency.