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The historical basis of a misconception leading to undertreating atopic dermatitis (eczema): facts and controversies.

机译:错误观念导致特应性皮炎(湿疹)治疗的历史基础:事实和争议。

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摘要

The quest for clarifying the pathophysiology of atopic dermatitis (eczema) has lasted for 25 centuries. Yearning to discern the primum movens of atopic dermatitis, physicians aimed to identify the curative therapy. Recent scientific efforts has brought to the light an ever-growing amount of interplaying pathophysiologic factors, including the epidermal barrier, the digestive flora, food, early infections and antigenic stimulations, and innate and adaptive immune response; however, overfocusing on some of these factors, along with misconceptions about the benefit/risk balance of topical therapies, has sometimes led topical therapies being disregarded. Reviewing the history of pathophysiologic concepts, we aim to return topical therapies to the center of the clinical management of atopic dermatitis.
机译:澄清特应性皮炎(湿疹)的病理生理学的探索持续了25个世纪。渴望识别特应性皮炎的原始运动,医生的目标是确定治疗方法。最近的科学努力揭示了越来越多的相互作用的病理生理因素,包括表皮屏障,消化菌群,食物,早期感染和抗原刺激以及先天性和适应性免疫反应;然而,过度关注这些因素中的一些,以及对局部治疗的获益/风险平衡的误解,有时导致局部治疗被忽视。回顾病理生理学概念的历史,我们旨在将局部疗法返回到特应性皮炎临床管理的中心。

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