Preparation and characterization of hyperbranched polyester conjugate of ciprofloxacin and its in vitro drug release studies

摘要

Hyperbranched polyester (HBP) based on the 3,5-dihydroxy benzoic acid was prepared by the self-poly condensation under standard trans-esterification conditions. The polyester possesses excellent solubility in common organic solvents. Molecular weight and intrinsic viscosity was determined by viscosity measurements. HBP has potential to act as efficient drug carrier systems. Using, ciprofloxacin hydrochloride drug as a model drug, studied the interaction between the drug and hyperbranched polyester with OH functionality. Analysis of the drug release was done by in vitro dissolution apparatus at pH 7.4 (phosphate buffer) media to understand the nature of transport of drug containing solution through the polymeric material. The results demonstrated that the HBP-drug was gradually release (10.4 %) the drug with phosphate buffer medium at 35 °C over a period of 24 h.