Quantitative LC-MS/MS determination of flupirtine, its N-acetylated and two mercapturic acid derivatives in man

Scheuch Eberhard; Methling Karen; Bednarski Patrick J.; Oswald Stefan; Siegmund Werner

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Quantitative LC-MS/MS determination of flupirtine, its N-acetylated and two mercapturic acid derivatives in man

机译：LC-MS / MS定量测定人中氟吡汀，其N-乙酰化和两种巯基酸衍生物

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摘要

The non-opiate analgesic drug flupirtine was shown in vitro to undergo hydrolysis followed by N-acetylation to form D13223, glucuronidation and conjugation with glutathione to form the stable mercapturic acid derivatives M-424 and M-466.

机译：非阿片类镇痛药氟吡汀在体外进行水解，然后进行N-乙酰化以形成D13223，葡糖醛酸化并与谷胱甘肽结合形成稳定的巯基酸衍生物M-424和M-466。

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《Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis》 |2015年第null期|共9页
作者
Scheuch Eberhard; Methling Karen; Bednarski Patrick J.; Oswald Stefan; Siegmund Werner;
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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Flupirtine; D-13223; Quantification; LC-MS/MS; Pharmacokinetics;

机译：氟吡汀;D-13223;定量;LC-MS / MS;药代动力学;

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1. Quantitative LC-MS/MS determination of flupirtine, its N-acetylated and two mercapturic acid derivatives in man [J] . Scheuch Eberhard, Methling Karen, Bednarski Patrick J., Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2015,第Null期

机译：LC-MS / MS定量测定人中氟吡汀，其N-乙酰化和两种巯基酸衍生物
2. LC-MS Method Development for Simultaneous Determination of Trans-3'-hydroxycotinine and Three Mercapturic Acids in Urine [J] . L. V. Lopukhov, A. V. Laikov, V. A. Romanova, BioNanoscience . 2018,第3期

机译：LC-MS方法开发，用于同时测定尿液中的Trans-3'-羟基霉素和三种巯基酸
3. LC-MS Method Development for Simultaneous Determination of Trans-3′-hydroxycotinine and Three Mercapturic Acids in Urine [J] . L. V. Lopukhov, A. V. Laikov, V. A. Romanova, BioNanoscience . 2018,第3期

机译：LC-MS方法开发，用于同时测定尿液中的Trans-3'-羟基霉素和三种巯基酸
4. LC-MS/MS Analysis of Mercapturic Acids: Addressing Selectivity and Matrix Effect Issues [C] . Alan Dzerk, Veni N. Lapko, Ridha Nachi, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

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Quantitative LC-MS/MS determination of flupirtine, its N-acetylated and two mercapturic acid derivatives in man

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