Factors Affecting the Upper Limit of the Methotrexate (MTX) CSF Levels Achievable in Children With Brain Tumors Treated With High-dose Intravenous MTX

Zemer Vered Shkalim; Toledano Helen; Ash Shifra; Cohen Eytan; Yaniv Isaac; Cohen Ian J.

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Factors Affecting the Upper Limit of the Methotrexate (MTX) CSF Levels Achievable in Children With Brain Tumors Treated With High-dose Intravenous MTX

机译：大剂量静脉MTX治疗脑肿瘤患儿可达到的甲氨蝶呤（MTX）CSF水平上限的影响因素

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Background: Little has been published in the medical literature on serum and cerebrospinal fluid (CSF) methotrexate (MTX) levels in children with brain tumors.

机译：背景：关于脑肿瘤儿童的血清和脑脊液（CSF）甲氨蝶呤（MTX）水平的医学文献很少发表。

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来源
《Journal of pediatric hematology/oncology: Official journal of the American Society of Pediatric Hematology/Oncology 》 |2016年第7期| 共5页
作者
Zemer Vered Shkalim; Toledano Helen; Ash Shifra; Cohen Eytan; Yaniv Isaac; Cohen Ian J.;
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正文语种 eng
中图分类儿科学 ;
关键词
high-dose methotrexate; childhood brain tumors; CSF; pharmacokinetics;

机译：大剂量甲氨蝶呤;儿童脑肿瘤;脑脊液;药代动力学;

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1. Factors Affecting the Upper Limit of the Methotrexate (MTX) CSF Levels Achievable in Children With Brain Tumors Treated With High-dose Intravenous MTX [J] . Zemer Vered Shkalim, Toledano Helen, Ash Shifra, Journal of pediatric hematology/oncology: Official journal of the American Society of Pediatric Hematology/Oncology . 2016 ,第7期

机译：大剂量静脉MTX治疗脑肿瘤患儿可达到的甲氨蝶呤（MTX）CSF水平上限的影响因素
2. Letter to the editor in response to the article "Clinical characteristics and risk factors for low dose methotrexate toxicity: a cohort of 28 patients" by Kivity S, Zafrir Y, Loebstein R, Pauzner R, Mouallem M, Mayan H, Autoimmun Rev. 2014 Nov.;13(11):1109-13 Height of MTX-PG levels in low-dose MTX-toxicity differs according to the time of onset [J] . Wassenaar Sophie, den Boer Ethan, Westerman Elsbeth M., Autoimmunity reviews . 2016 ,第11期

机译：Kivity S，Zafrir Y，Loebstein R，Pauzner R，Mouallem M，Mayan H，Autoimmun Rev. 2014年对文章“低剂量甲氨蝶呤毒性的临床特征和危险因素：28名患者的队列”致编辑的信Nov.; 13（11）：1109-13低剂量MTX毒性中MTX-PG水平的高度因发病时间而异
3. Triple Oral Therapy Versus Antitumor Necrosis Factor Plus Methotrexate (MTX) in Patients with Rheumatoid Arthritis and Inadequate Response to MTX: A Systematic Literature Review [J] . Mary Julia, De Bandt Michel, Lukas Cedric, The Journal of rheumatology . 2017 ,第6期

机译：三倍口腔治疗与抗肿瘤坏死因子加甲氨蝶呤（MTX），患者有类风湿性关节炎，对MTX的反应不足：系统文献综述
4. Treatment of Recurrent Post-transplant LymphoproIIferative Disorder (PTLD) of the Central Nervous System (CNS) with High-dose Methotrexate (HD-MTX) [C] . Twist C.J., Kjelson L., McKenney A., International Small Bowel Transplant Symposium . 2009

机译：用高剂量甲氨蝶呤（HD-MTX）的中枢神经系统（CNS）复发性移植后移植淋巴结疾病（PTLD）的处理
5. Central Nervous System Injury, Neurocognitive and Quality of Life Outcomes in Children with Brain Tumors Treated with Chemotherapy. [D] . Baron Nelson, Mary Christine. 2012

机译：化学疗法治疗脑肿瘤患儿的中枢神经系统损伤，神经认知和生活质量。
6. MBCL-33. HEPATOTOXICITY DURING INDUCTION CHEMOTHERAPY WITH OR WITHOUT HIGH-DOSE METHOTREXATE (HD-MTX) ON THE HEAD START II TRIAL FOR PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS [O] . Mohammad H Abu Arja, Lubna S Mehyar, Diana S Osorio, 2018

机译：MBCL-33。高剂量甲氨蝶呤（HD-MTX）或无高剂量甲氨蝶呤（HD-MTX）诱导化学疗法期间的肝毒性在原发性中枢神经系统（CNS）肿瘤的II期临床试验中
7. Improving the safety of high-dose methotrexate for children with hematologic cancers in settings without access to MTX levels using extended hydration and additional leucovorin [O] . Kalthi Vaishnavi, Deepak Bansal, Amita Trehan, 2018

机译：在环境中提高血液学癌症的儿童的高剂量甲氨蝶呤的安全性，无需使用延长的水合和额外的Leucovorin获得MTX水平

Factors Affecting the Upper Limit of the Methotrexate (MTX) CSF Levels Achievable in Children With Brain Tumors Treated With High-dose Intravenous MTX

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