y acting as a positive GABA(A) modulator and showing anxiolytic and sedative behavioural effects. Results showed that bilateral intrahippocampal 5 ng of PregS deteriorated passive avoidance retention but also presented an anxiogenic-like profile in the open field test, decreasing the locomotion and the time spent in the central zone without affecting either total activity or time spent in the periphery of the field (thigmotaxis). AlloP administration did not affect passive avoidance retention, a