Rare indications of IVIG therapy in neurological diseases based on case reports and small studies.

摘要

IVIG treatment has been tried in several neurological diseases with presumed immuno-pathogenesis. Many of the rare neurological diseases seem to benefit from IVIG treatment; however, negative results have been rarely published. Despite the majority of positive results, a general use of IVIG cannot be recommended for these diseases. Beside the lack of controlled studies and the small numbers of reported cases, a publication bias has to be considered since negative study results are usually not reported. Therefore, at this stage treatment with IVIG should be used in conjunction with controlled therapy trials.