Relapse risk in patients with multiple sclerosis after H1N1 vaccination, with or without seasonal influenza vaccination.

摘要

The safety of vaccination in multiple sclerosis (MS) raises concern, particularly the relapse risk post-vaccination. With the recent H1N1 pandemic, people with chronic diseases, including neurological conditions such as MS, were prioritised for vaccination. Two questions therefore arise in this context: whether vaccination increases the relapse rate, and whether the relapse is more severe post-vaccination. Seasonal influenza immunisation does not increase the risk of MS exacerbation; a systematic review found no increased risk of early (3-4 weeks post-vaccination) or late (4-6 months) exacerbations [1].