Rhabdomyolysis induced by severe levodopa induced dyskinesia in a patient with Parkinson's disease.

摘要

A 74-year-old man with Parkinson's disease (PD) who had been regularly taking levodopa for 17 years developed severe generalized dyskinesia of choreiform movement. He began to show bradykinesia and rigidity in right limbs *at age 57 years. Levodopa treatment dramatically improved his parkinsonian symptoms. Three years after levodopa treatment, he began to feel wearing-off. At age 72 years, he suffered from levodopa-induced dyskinesia (LID) during levodopa on period and was immobile during the off period. Seven days before his first visit to emergency room, he began to feel deterioration of his symptoms with levodopa/ carbidopa 250/25 mg q.i.d. and controlled-release form of levodopa/benserazide 100/25 mg q.i.d. Although peak dose dyskinesia gradually worsened, he gradually increased the dosage until he was taking 12 tablets of levodopa/carbi-dopa 250/25 mg and four tablets of levodopa/benserazide 100/25 mg per day.